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doi: 10.1016/j.maturitas.2017.01.016 243 JensenLBVestergaardPHermannAPGramJEikenPAbrahamsenBet al

The absence of published bioavailability studies, coupled with theoretical limitations, suggests that berberine patches are unlikely to deliver therapeutically relevant amounts of the compound into systemic circulation

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Gradual increases: The dose continues to increase every four weeks, going up to 1 mg, 1.7 mg, and finally 2.4 mg once a week, which is the target dose for weight loss